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Item Number: AG-010100


AmnioMTM Injectable Multi-Potential Tissue Matrix. 0.25ml

Engineered by Nature to Potentiate Wound Healing and Bone Regeneration AmnioMTM™ is a novel, multipotential extracellular matrix (ECM) which acts as a natural scaold for cellular attachment. While providing structural support to cells, AmnioMTM™ assists in regulating cell adhesion, cell division, and cell migration.


Introducing AmnioMTM, a cryopreserved amnion allograft, derived from the placenta of live, healthy donors.  The human placenta, besides playing a

critical and fundamental role in fetal development, nutrition and protection, represents a significant source of multipotent stem cells and fetal healing

components.  AmnioMTM provides a three dimensional extracellular matrix, which acts as a natural scaffold for cellular attachment in the body.

AmnioMTM also contains multipotential cells that are capable of differentiating into all three germ layers of the human body. The ECM houses and

provides structural support to cells while regulating cell adhesion, cell division, cell differentiation, and cell migration. Together in this complex, dynamic

bone and wound healing system, AmnioMTM delivers osteogenic, osteoconductive and osteoinductive  elements to enhance and proliferate wound and

bone healing and repair Amniotic allografts have been scientifically documented and clinically proven to be efficacious in a wide array of surgical applications

ranging from: anti-adhesion, anti-inflammatory barrier in spinal laminectomies,ocular surface ophthalmic procedures, and diabetic wound care management.

Potential Applications:

Wound Covering

Ridge Augmentation

Soft Tissue Repair

Periodontal Defects

Boney Defects


Multipotent Cells Identified to be Present within Amniotic Membrane Tissue:

Amniotic Epithelial Cells

Amniotic Mesenchymal Cells

Growth Factors Identified to be Present within Amniotic Membrane Tissue: EGF, TGF-β, FGF, PDGF A & B, VEGF, IGF 1 & 2

Bio-Active Design AmnioMTM™ retains the natural composition of extracellular matrix molecules including collagen, structural proteins, growth factors, glycoproteins, and glycosaminoglycans.

Presence of multipotent cells may have bi-potential osteogenic and adipogenic differentiation capabilities.

AmnioMTM™ has anti-inflammatory, anti-microbial, anti-bacterial, and anti-adhesive as well as immunoprivileged properties.



  Immune privileged; Class II anti-gens not expressed, reducing the risk of immunological rejection.
β-defensins, anti-microbial peptides, inhibit bacterial infections.
            Multipotential cells capable of differentiating, providing ancillary healing benefits.
            The extracellular matrix creates a native scaffold for supporting wound and bone healing.
    Derived from live, healthy donors.

A Dynamic Bone and Wound Healing System

Amniotic Morselized Tissue
Has been shown to be immune privileged (Class II antigens rarely expressed) anti-microbial, anti-bacterial.
Donor source from live healthy patients resulting in less complications and donor rejection versus traditional allografts, xeno-
 grafts. And compared to autografts, there is no need for a second surgical procedure to harvest bone resulting in less site morbidity, pain
  and associated costs.
Three Dimensional Extracellular Matrix Scaffold
          Provides mechanical properties such as collagen I-VI and elastin creating osteoconductive environment for cell attachment and hosting.
            Provides structural matrix for use in filling soft tissue defects and bone voids.

          Fibronectin, Laminins, Vitronectin and Cytokines.
          Proteins from the ECM that signal cells to attach and migrate. Serve as adhesion ligands and allows for intercellular communication.
            Rarely evokes an immune response with patients experiencing less pain, swelling and inflammation.
          Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF- β Fibroblast Growth Factor (FGF),
          Platelet Derived Growth Factor A&B ( PDGF A&B)
          EGF proliferates epithelial cells. TGF-β acts as an anti-inflammatory, reduces scar tissue, speeding up healing. FGF proliferates cells for
          collagen matrix. PDGF A&B proliferates connective tissue and enhances soft tissue
         Has been shown to accelerate wound healing rates, bone formation and soft tissue attachment. Also healthcare economics
         are positive when comparing AmnioMTM to other osteoinductive and osteogenic materials or synthetic products.
         Hyaluronic Acid
             It’s been reported to increase osteoblastic bone formation in vitro through increased mesenchymal cell
          differentiation and cell migration.
          Has the potential to reduce scar formation and improve vascularity, resulting in better tissue formation.

Product Characteristics FDA-registered product regulated under 21 CFR Part 1271 and Section 361 of the Public Health Service Act. Cryopreserved liquid allograft, derived from live birth tissue and cells, which is not dependent on the metabolic activity of living cells. Extensive donor selection and screening, according to AATB guidelines, is performed to ensure clinical safety. For homologous use only. *******PLEASE CALL FOR SHIPPING DETAILS. PRODUCT IS ORDERED PER CASE, OR A CRYO FREEZER CAN BE MADE AVAILABLE. SHIPPED IN CRYO PRESERVED PACKAGE, WITH 4 DAY SHIP WINDOW. - CALL FOR FURTHER DETAILS

Case Studies

Lateral Ridge Augmentation Using AmnioMTM™

Case Report Soft Tissue Grafting Using AmnioMTM™ to Treat Gingival Recession

Soft Tissue Grafting Using Acellular Dermal Matrix with AmnioMTM™

Use of AmnioMTM™in Guided Tissue Regeneration in Severe Periodontitis

Alveolar Fenestration Repair and Simultaneous Sinus Augmentation Using AmnioMTM™



Please follow the links for Clinical material on the use of Amnion based material in Medicine

Available PDF Articles

Basic Science

Properties of the Amniotic Membrane for Potential Use in Tissue Engineering


How do Mesenchymal Stem Cells Repair


Amniotic Fluid and Placental Stem Cells


Human Amnion Tissue as an Antiadhesion AntiInflammatory Barrier in an Ovine Laminectomy Model


Not Just Fetal Urine Anymore


Scarless Skin Wound Repair in the Fetus


Term Amniotic Membrane is a High throughout Source for Multipotent Mesenchymal Stem Cells


Inducing of Angiogenesis is the net effect of the Amniotic Membrane without Epithelial Cells


Scarless Fetal Healing


Amniotic Healing in Dental 

A Prospective Pilot Study on the Clinical Application of Stromal Vascular Fraction Stem Cells in Treatment Gingival Recession Defects


Histological and Computed Tomography Analysis of Amnion Chorion Membrane in Guided Bone Regeneration in Socket Augmentation


Cryopreserved Amniotic Membrane for Modulation of Periodontal Soft Tissue Healing


Wound Healing

Amniotic Membrane as a Biological Dressing in the Management of Burns


Human Amnion as an Adjunct in Wound Healing


Human Amniotic Membrane A Versatile Wound Dressing


In Vitro Angiogenesis on the Human Amniotic Membrane


A Comparative Histopathological Investigation of the Effect of Lyophilized Amniotic Membrane on Wound Healing


Amniotic Membrane Allograft for Treatment in Diabetic Wound Care Management


Amniotic Membrane Dressing Versus Conventional Dressing in Lower Limb Varicose Ulcer


Bone Healing

Effect of Human Amniotic Fluid on Fracture Healing in Rat Tibia


Effect of Human Amniotic Fluid on Bone Healing


Efficacy of a Novel Cell Based Therapy on Bone Healing in a Critical Sized Rat Femur Defect


Amniotic Healing in Medicine

Isolation of Amniotic Stem Cell Lines with Potential for Therapy  


Surface Amniotic Membrane Transplantation has Many Advantages


Immunogenicity of Human Amnion Epethial Cells After Transplantation into Volunteers


Implantation of Amniotic Membrane to Reduce Postlaminectomy of Epidural Adhesions


Use of Amniotic Membrane Transplantation in the Treatment of Venous Leg Ulcers


Versatile Biomaterial Suitable for Treaty Acute Ocular Traumatic Injuries