AmnioMTM Injectable Multi-Potential Tissue Matrix. 0.25ml
Engineered by Nature to Potentiate Wound Healing and Bone Regeneration AmnioMTM™ is a novel, multipotential extracellular matrix (ECM) which acts as a natural scaold for cellular attachment. While providing structural support to cells, AmnioMTM™ assists in regulating cell adhesion, cell division, and cell migration.
Introducing AmnioMTM, a cryopreserved amnion allograft, derived from the placenta of live, healthy donors. The human placenta, besides playing a
critical and fundamental role in fetal development, nutrition and protection, represents a significant source of multipotent stem cells and fetal healing
components. AmnioMTM provides a three dimensional extracellular matrix, which acts as a natural scaffold for cellular attachment in the body.
AmnioMTM also contains multipotential cells that are capable of differentiating into all three germ layers of the human body. The ECM houses and
provides structural support to cells while regulating cell adhesion, cell division, cell differentiation, and cell migration. Together in this complex, dynamic
bone and wound healing system, AmnioMTM delivers osteogenic, osteoconductive and osteoinductive elements to enhance and proliferate wound and
bone healing and repair Amniotic allografts have been scientifically documented and clinically proven to be efficacious in a wide array of surgical applications
ranging from: anti-adhesion, anti-inflammatory barrier in spinal laminectomies,ocular surface ophthalmic procedures, and diabetic wound care management.
Soft Tissue Repair
Multipotent Cells Identified to be Present within Amniotic Membrane Tissue:
Amniotic Epithelial Cells
Amniotic Mesenchymal Cells
Growth Factors Identified to be Present within Amniotic Membrane Tissue: EGF, TGF-β, FGF, PDGF A & B, VEGF, IGF 1 & 2
Bio-Active Design AmnioMTM™ retains the natural composition of extracellular matrix molecules including collagen, structural proteins, growth factors, glycoproteins, and glycosaminoglycans.
Presence of multipotent cells may have bi-potential osteogenic and adipogenic differentiation capabilities.
AmnioMTM™ has anti-inflammatory, anti-microbial, anti-bacterial, and anti-adhesive as well as immunoprivileged properties.
Immune privileged; Class II anti-gens not expressed, reducing the risk of immunological rejection.
β-defensins, anti-microbial peptides, inhibit bacterial infections.
Multipotential cells capable of differentiating, providing ancillary healing benefits.
The extracellular matrix creates a native scaffold for supporting wound and bone healing.
Derived from live, healthy donors.
A Dynamic Bone and Wound Healing System
Amniotic Morselized Tissue
Has been shown to be immune privileged (Class II antigens rarely expressed) anti-microbial, anti-bacterial.
Donor source from live healthy patients resulting in less complications and donor rejection versus traditional allografts, xeno-
grafts. And compared to autografts, there is no need for a second surgical procedure to harvest bone resulting in less site morbidity, pain
and associated costs.
Three Dimensional Extracellular Matrix Scaffold
Provides mechanical properties such as collagen I-VI and elastin creating osteoconductive environment for cell attachment and hosting.
Provides structural matrix for use in filling soft tissue defects and bone voids.
Fibronectin, Laminins, Vitronectin and Cytokines.
Proteins from the ECM that signal cells to attach and migrate. Serve as adhesion ligands and allows for intercellular communication.
Rarely evokes an immune response with patients experiencing less pain, swelling and inflammation.
Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF- β Fibroblast Growth Factor (FGF),
Platelet Derived Growth Factor A&B ( PDGF A&B)
EGF proliferates epithelial cells. TGF-β acts as an anti-inflammatory, reduces scar tissue, speeding up healing. FGF proliferates cells for
collagen matrix. PDGF A&B proliferates connective tissue and enhances soft tissue
Has been shown to accelerate wound healing rates, bone formation and soft tissue attachment. Also healthcare economics
are positive when comparing AmnioMTM to other osteoinductive and osteogenic materials or synthetic products.
It’s been reported to increase osteoblastic bone formation in vitro through increased mesenchymal cell
differentiation and cell migration.
Has the potential to reduce scar formation and improve vascularity, resulting in better tissue formation.
Product Characteristics FDA-registered product regulated under 21 CFR Part 1271 and Section 361 of the Public Health Service Act. Cryopreserved liquid allograft, derived from live birth tissue and cells, which is not dependent on the metabolic activity of living cells. Extensive donor selection and screening, according to AATB guidelines, is performed to ensure clinical safety. For homologous use only. *******PLEASE CALL FOR SHIPPING DETAILS. PRODUCT IS ORDERED PER CASE, OR A CRYO FREEZER CAN BE MADE AVAILABLE. SHIPPED IN CRYO PRESERVED PACKAGE, WITH 4 DAY SHIP WINDOW. - CALL FOR FURTHER DETAILS
Lateral Ridge Augmentation Using AmnioMTM™
Case Report Soft Tissue Grafting Using AmnioMTM™ to Treat Gingival Recession
Soft Tissue Grafting Using Acellular Dermal Matrix with AmnioMTM™
Use of AmnioMTM™in Guided Tissue Regeneration in Severe Periodontitis
Alveolar Fenestration Repair and Simultaneous Sinus Augmentation Using AmnioMTM™
Please follow the links for Clinical material on the use of Amnion based material in Medicine
Available PDF Articles
Properties of the Amniotic Membrane for Potential Use in Tissue Engineering
How do Mesenchymal Stem Cells Repair
Amniotic Fluid and Placental Stem Cells
Human Amnion Tissue as an Antiadhesion AntiInflammatory Barrier in an Ovine Laminectomy Model
Not Just Fetal Urine Anymore
Scarless Skin Wound Repair in the Fetus
Term Amniotic Membrane is a High throughout Source for Multipotent Mesenchymal Stem Cells
Inducing of Angiogenesis is the net effect of the Amniotic Membrane without Epithelial Cells
Scarless Fetal Healing
Amniotic Healing in Dental
A Prospective Pilot Study on the Clinical Application of Stromal Vascular Fraction Stem Cells in Treatment Gingival Recession Defects
Histological and Computed Tomography Analysis of Amnion Chorion Membrane in Guided Bone Regeneration in Socket Augmentation
Cryopreserved Amniotic Membrane for Modulation of Periodontal Soft Tissue Healing
Amniotic Membrane as a Biological Dressing in the Management of Burns
Human Amnion as an Adjunct in Wound Healing
Human Amniotic Membrane A Versatile Wound Dressing
In Vitro Angiogenesis on the Human Amniotic Membrane
A Comparative Histopathological Investigation of the Effect of Lyophilized Amniotic Membrane on Wound Healing
Amniotic Membrane Allograft for Treatment in Diabetic Wound Care Management
Amniotic Membrane Dressing Versus Conventional Dressing in Lower Limb Varicose Ulcer
Effect of Human Amniotic Fluid on Fracture Healing in Rat Tibia
Effect of Human Amniotic Fluid on Bone Healing
Efficacy of a Novel Cell Based Therapy on Bone Healing in a Critical Sized Rat Femur Defect
Amniotic Healing in Medicine
Isolation of Amniotic Stem Cell Lines with Potential for Therapy
Surface Amniotic Membrane Transplantation has Many Advantages
Immunogenicity of Human Amnion Epethial Cells After Transplantation into Volunteers
Implantation of Amniotic Membrane to Reduce Postlaminectomy of Epidural Adhesions
Use of Amniotic Membrane Transplantation in the Treatment of Venous Leg Ulcers
Versatile Biomaterial Suitable for Treaty Acute Ocular Traumatic Injuries